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Index > Protein center > Lnx1(Gene name) > Mouse
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  • Lnx1 (Gene name),
  • E3 ubiquitin-protein ligase LNX (Protein name ),  LNX1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lnx1(Lnx);
    Protein name:
    E3 ubiquitin-protein ligase LNX;
    Alternative:
    Ligand of Numb-binding protein 1;Ligand of Numb protein X 1;Numb-binding protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CXADR (By similarity). Interacts with the phosphotyrosine interaction domain of all isoforms of NUMB. IGSF5/JAM4 interacts with isoform 2 through the second PDZ domain, other isoforms may also interact with IGSF5/JAM4.
    Function:
    Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    728
    Sequence:
    50:
    MNQPDLADDP | DPSPEPLCIV | CGQNHSPEEN | HFYTYTEDVD | DDLICHICLQ | 
    100:
    ALLDPLDTPC | GHTYCTLCLT | NFLVEKDFCP | VDRKPVVLQH | CKKSSILVNK | 
    150:
    LLNKLLVTCP | FTEHCTEVLQ | RCDLQHHFQT | SCKGASHYGL | TKDRKRRSQD | 
    200:
    GCPDGCASLM | ATTLSPEVSA | AATISLMTDE | PGLDNPAYVS | SVEDGEPVAN | 
    250:
    SSDSGRSNRT | RARPFERSTM | RSRSFKKINR | ALSALRRTKS | GSVVANHVDQ | 
    300:
    GRDNSENTTV | PEVFPRLFHL | IPDGEITSIK | INRADPSESL | SIRLVGGSET | 
    350:
    PLVHIIIQHI | YRDGVIARDG | RLLPGDIILK | VNGMDISNVP | HNYAVRLLRQ | 
    400:
    PCQVLRLTVL | REQKFRSRSN | AHVPDSYGPR | DDSFHVILNK | SSPEEQLGIK | 
    450:
    LVRRVDEPGV | FIFNVLNGGV | ADRHGQLEEN | DRVLAINGHD | LRFGSPESAA | 
    500:
    HLIQASERRV | HLVVSRQVRQ | SSPDIFQEAG | WISNGQQSPG | PGERNTASKP | 
    550:
    AATCHEKVVS | VWKDPSESLG | MTVGGGASHR | EWDLPIYVIS | VEPGGVISRD | 
    600:
    GRIKTGDILL | NVNGIELTEV | SRTEAVAILK | SAPSSVVLKA | LEVKEQEAQE | 
    650:
    DCSPAALDSN | HNVTPPGDWS | PSWVMWLELP | QYLCNCKDVI | LRRNTAGSLG | 
    700:
    FCIVGGYEEY | SGNKPFFIKS | IVEGTPAYND | GRIRCGDILL | AVNGRSTSGM | 
    728:
    IHACLARMLK | ELKGRITLTI | ASWPGTFL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    E13521h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    E13521m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    U13521h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    U13521m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    P13521Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase LNX
    Cat.:
    P13521Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase LNX
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase LNX
    Protein for Mouse E3 ubiquitin-protein ligase LNX
    Protein for Mouse E3 ubiquitin-protein ligase LNX

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX."
      Dho S.E. , Jacob S. , Wolting C.D. , French M.B. , Rohrschneider L.R. , McGlade C.J.
      J. Biol. Chem.273:9179-9187(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY;MUTAGENESIS OF PRO-181; GLY-182; LEU-183; ASP-184; ASN-185; PRO-186 AND TYR-188
      tissue: Brain.
      tissue: Embryo.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Brain cortex.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Eye.
    4. 4.
      "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation."
      Nie J. , McGill M.A. , Dermer M. , Dho S.E. , Wolting C.D. , McGlade C.J.
      EMBO J.21:93-102(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN NPXY MOTIF;MUTAGENESIS OF CYS-48
    5. 5.
      "A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb."
      Nie J. , Li S.S.-C. , McGlade C.J.
      J. Biol. Chem.279:20807-20815(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAINS PDZ;INTERACTION WITH NUMB
    6. 6.
      "Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4."
      Kansaku A. , Hirabayashi S. , Mori H. , Fujiwara N. , Kawata A. , Ikeda M. , Rokukawa C. , Kurihara H. , Hata Y.
      Oncogene25:5071-5084(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGSF5
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